Vsevolod: Fluff: When your consciosness is not clear, you can not sleep even with the relaxation teas. So, here we go I am awake. Need to write a one page report related to Electrolytes. Textbook is availible. Catch up with the clinical chemistry. Calendar is availible. Needs to be organized.
Sam: Proceeding you must organize employment history. Alabama Jobs organized, Oklahoma not organized. RGIS checks are on place.
Vsevolod: I am late with the report. It was not on the calendar. Well, I did not put it there. Dang. So, I must choose easier topic so we can brainstrorm it. Also, I take calendar and put every single Assignment in there. So, that's what the calendars are for. Test on the 18th; case studies on the 13th.
Sam:What is the topic?
Vsevolod: If we choose to describe ionic compounds, too much scrutiny. It is 4.45 am. We have 2 hours. So, I choose: "Water, and Osmolarity, Clinical Significance of Osmolality"
Vsevolod: Pre writing discussion. Diagram illustrating Osmolality of the Intestinal Fluids.
Sam: The osmolarity diagram discussed.
Vsevolod: Osmolality is the concentration of solutes per weight of solvent. The diagramm illustrates what's going on inside the interstitial fluids. Cortex - low osmolarity, Outer Medulla - higher, Inner Medulla - high. Notice particles are transported via different types of transport in the loop. Salt (NaCl) active transport -ENERGY. Water: passive transport - NO ENERGY. Section with a lot of water, and not enough water. Albeit, the water load, and water deficit. Water load begins at lower osmolarity, water deficit begins at higher osmolality. The hormonal regulation connects to hunger, thirst.
AVP hormone gives a sensation of thirst; secretes in the posterior pituitary gland; acts on the cells in the collecting duct. As water is conserved osmolarity decreases, turning off AVP secretion.
- Category: Clinical Science
One Page Paper Report
Vsevolod Koudriavtsev
Chapter 15 Report – Water, Osmolality, and Hormonal Regulation
Water is the universal solvent. It is a significant component of a human body. The average water content in men and woman ranges from forty to seventy percent depending on the age, the sex, the weight, and the other factors. Water removes waste, regulates the volume of cells, acts as a solvent, cools the body, and transports the nutrient components. Water plays a significant role in the process known as the osmoregulation. Membranes form two sides based on their permeability characteristics: a side with a higher water concentration, and a side with a higher ions/proteins concentration. Osmoregulation influences the flow of water across the membrane.
Concentration of water and solutes has been studied while taking in the account the physical property of a solution known as the osmolality which takes into the account a concentration of solute, and concentration of solvent as the rate (concentration of the solute/ concentration of the solvent or concentration of the solute/ volume of the solvent). Water load and water deficit provide a different physiological phases based on the osmolality, and the water content. During the water load, osmolality decreases, hormones associated with the water deficit are suppressed. Deficit of water increases osmolality, and activates hormones which may signal thirst.
Understanding the basics described above enables students to discuss a medical conditions associated with the hormonal regulation. The hormone known as the Arginine Vasopressin Hormone plays a role of a thirst activator. Two percent increase/decrease in osmolality activates/shuts off a hormone, which has a life time of 15-20 minutes.
References: Bishop.Michael. 'Clinical Chemistry'. Wolters Kluwer. 2010. New York. 6th edition
Vsevolod: Yes, the report is not perfect, but it is enough for the instructions gave by my instructor. And now I have the concept of osmoregulation, osmolarity, and hormonal regulation in the long term memory.
Sam: Yes.
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